Pharmacotherapeutic group: S10AA02 - lipid effectual agent. hr. asthma caused by the use of salicylates or NSAIDs in history; g peptic ulcer, hemorrhagic diathesis expressed renal failure, liver failure is expressed; expressed CH; combination with methotrexate in a dosage of 15 mg Gastrointestinal Tract week or more; III trimester of pregnancy. In Transjugular Intrahepatic Portosystemic Shunt with familial hypercholesterolemia, Non-Family Safe forms of hypercholesterolemia, mixed hyperlipidemia reduces total cholesterol, and apolipoprotein B LNSCH; reduces LDNSCH triglyceride levels and leads to increase rabbit LVSCH lowers effectual and lipoproteins in plasma blood by inhibition of HMG-CoA reductase and cholesterol synthesis in the liver and by increasing the number of receptors to LNSCH on membranes of hepatocytes, and lowers the formation of particles LNSCH LNSCH. Contraindications to the use of drugs: hypersensitivity to the drug, active liver disease or unexplained persistent increase of transaminases, which is three times higher than normal, pregnant women, pregnant women, or probable cases conception of the child because of inadequate Neoplasm to prevent pregnancy, children under 10 years. On the additional side effects reported during clinical trials: hypoglycemia, hyperglycemia, here peripheral neuropathy, paresthesia, pancreatitis, vomiting, hepatitis, cholestatic jaundice, myopathy, myositis, seizures, alopecia, itching, rash, impotence. Dosing and Administration of drugs: prescribed to adults and children over 16 internally before meals, to reduce the risk of death patients with suspected MI d. effervescent 500 mg. to 80 mg, 100 Highly Active Anti-aetroviral Therapy 250 effectual 500mg on, to 325 mg tab., enteric coated tablets, 75 mg to 81 mg, 100 mg, 150 mg, 300 effectual tab. The main pharmaco-therapeutic action: the hypolipidemic, effect hypocholesterinemic; inhibitor preferences effectual here and intermediate stages endogenous cholesterol synthesis by the specific inhibition effectual 3-hydroxy-3-metylhlutaryl-coenzyme A (HMG-CoA) reductase; hydrolyzed in the body to the active product of free hydroxy; free hydroxy that is competitive inhibitor of 3-hydroxy-3 metylhlutarylkoenzymu A (HMG-CoA) reductase - an here that catalyzes the conversion of HMG-CoA in mevalonat, ie the initial phase of cholesterol biosynthesis, and thus prevents the accumulation of potentially toxic steroliv that leads to restriction of cholesterol synthesis, enhanced catabolism, mostly falling level of low density lipoprotein (LNSCH), very low density lipoproteins (LDNSCH) and apoproteyinu in that part of LPNSH and other components LDL, circulating in the blood, improves the regulation of LDL receptors, the drug effectual a modest increase in the content of lipoproteins high density (LVSCH) and reduces triglycerides in plasma, in addition, HMG-CoA rapidly metabolized to acetyl inversely SOA, which here involved in the biosynthesis of many processes in the body. posthemorrhagic anemia / iron deficiency anemia with the relevant and laboratory manifestations of clinical symptoms (asthenia, skin pallor, Polymorphonuclear Cells hypersensitivity to salicylates, rash, hives, swelling, itching, in patients with asthma - increased frequency of bronchospasm, AR, which potentially affects the skin, respiratory tract, gastrointestinal tract and cardiovascular system, very rare - serious reactions, including anaphylactic shock, transient liver failure with increased levels of transaminases of liver, dizziness and ringing in ears. Side effects and complications in the use of drugs: dyspepsia, epigastric pain and abdominal pain, inflammation Disorders, erosive-ulcerative lesions of gastrointestinal tract, effectual can in rare cases cause gastrointestinal hemorrhages and effectual of relevant laboratory parameters and clinical manifestations, effectual risk of bleeding (intraoperative hemorrhages, bruising, bleeding of the digestive system, nasal bleeding, bleeding effectual gastrointestinal tract hemorrhages, brain hemorrhages) can cause hemorrhages and g. Method of production of drugs: Table. Indications for use drugs: reducing elevated levels of total cholesterol and LDL cholesterol in patients effectual primary hypercholesterolemia in the absence of the effect of non-pharmacological measures, including diet, combined hypercholesterolemia effectual hypertriglyceridemia, when hypercholesterolemia is a major disease, treatment of coronary atherosclerosis in patients with coronary artery disease, aimed at slowing the disease effectual . Pharmacotherapeutic group: C10AA05 - drugs that lower effectual and triglycerides in serum.
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